We are experiencing a similar issue with MacOS 12.3 and later when Cisco AnyConnect 4.10.04071 or later is installed (incl. 4.10.05095). After install of AnyConnect Ping to IP address works DNS to any site fails netstat output for TCP and DNS sockets remain under 100 count. Cisco DART report shows "Description: DNSPLUGINMGR_ERROR_OPEN_PLUGIN_FAILED". After uninstalling AnyConnect, DNS resolution is fine. We reported issue to Apple and opened a case, submitting the information from the Capture_Data.dmg tools and Apple after a day moved the case to the Enterprise Team. Now they won't communicate with us. If anyone is experiencing this same issue on the M1 but not the Intel platform please let us know.