We had the same issue in our app where a UIButton had "forceRightToLeft" set for its semantic content mode, but it was set in the nib file. It was likely this was set so the order of the image and text in the UIButton were reversed (unfortunately this is currently the top accepted answer on Stack Overflow at the time of writing). Curiously we also discovered that VoiceOver in iOS 16 beta, unlike previous versions of iOS, will tell you "Directionality changed from right to left".

Same issue in beta 5 too