In my case, increasing Bitwig Studio's "Block size" from the Automatic setting of 256 samples to 512 samples almost entirely fixes the issue. Oddly, the same instruments with Bitwig studio on my 2010 Mac pro don't have any crackling issues even with block size set to 32 samples.

Found this thread while trying to diagnose a crackling sound with my M1 Max macbook pro (Ventura 13.2.1), mostly using Bitwig Studio. Tried killall coreaudiod, but that didn't work. Same program works fine on my 2010 Mac Pro (running Monterey). Interestingly, the Bitwig "DSP Performance Graph" shows sharp spikes coinciding with each of the crackles. Activity monitor shows absolutely no memory pressure (the machine has 64GB, isn't running much). Tried changing sample rate in Bitwig, which did show a different baseline in the DSP Performance Graph, but the spikes still happen. Very odd behavior.