If you accidentally denied SimulatorTrampoline to directories, you can explicitly set the permission back by following the instructions below. Find SimulatorTrampoline.xpc in Finder. (A quick way to do this is to open Finder and type SimulatorTrampoline.xpc into the search bar.) Open Security & Privacy > Privacy > Full Disk Access. Unlock to make changes. Drop the SimulatorTrampoline.xpc to apps area (it will be invisible). Quit SimulatorTrampoline.xpc if needed. Now all permissions are set. You can try to use simulator again. Hope this helps. :)