The warning appears when trying to create an instance of any audio unit provided by some specific manufacturers and to open it in its editor (both things being merged as a single operation). The message body was followed by another sentence :
macOS cannot verify that this app does not contain any malicious software
and
created this file today at 15:32
The file in question was a file called NSCreatedObjectFileImageFromMemory-p47UEwps stored in the temporary directory (-[NSURL temporaryDirectory]) of the host application.
The panel buttons proposed either to trash the file or to cancel. Whatever the button clicked, a second dialog appears with an exclamation mark in a red icon and the Fatal Error 100001 message, and the plugin never opened (but the host application didn't crash).
Here is a part of the crash report (if you want, I can send the full report to your email address):
Date/Time: 2023-08-24 15:04:45.7209 +0200
OS Version: macOS 12.5.1 (21G83)
Report Version: 12
Bridge OS Version: 6.6 (19P6066)
Anonymous UUID: 0495D4E2-3107-8006-D560-7301560EB3CE
Sleep/Wake UUID: 2CFC336A-EB4A-4493-BB08-8CCCBA20E12F
Time Awake Since Boot: 73000 seconds
Time Since Wake: 596 seconds
System Integrity Protection: enabled
Crashed Thread: 0 Dispatch queue: com.apple.main-thread
Exception Type: EXC_BAD_ACCESS (SIGBUS)
Exception Codes: KERN_PROTECTION_FAILURE at 0x0000000137c7cc34
Exception Codes: 0x0000000000000002, 0x0000000137c7cc34
Exception Note: EXC_CORPSE_NOTIFY
Termination Reason: Namespace SIGNAL, Code 10 Bus error: 10
Terminating Process: exc handler [41378]
VM Region Info: 0x137c7cc34 is in 0x137bb1000-0x137cc9000; bytes after start: 834612 bytes before end: 312267
REGION TYPE START - END [ VSIZE] PRT/MAX SHRMOD REGION DETAIL
mapped file 135c56000-137773000 [ 27.1M] r--/rwx SM=COW ...t_id=d8860195
GAP OF 0x43e000 BYTES
---> __TEXT 137bb1000-137cc9000 [ 1120K] r-x/rwx SM=COW ...le SSL 4000 G
__DATA 137cc9000-137cf5000 [ 176K] rw-/rwx SM=COW ...le SSL 4000 G
Thread 0 Crashed:: Dispatch queue: com.apple.main-thread
0 bx_console SSL 4000 G 0x137bdf476 0x137bb1000 + 189558
1 bx_console SSL 4000 G 0x137c7e739 AUV2AdapterEntry + 439641
2 dyld 0x1148ca334 dyld4::RuntimeState::notifyObjCInit(dyld4::Loader const*) + 170
3 dyld 0x1148cff03 dyld4::Loader::runInitializersBottomUp(dyld4::RuntimeState&, dyld3::Array<dyld4::Loader const*>&) const + 167
4 dyld 0x1148cffb2 dyld4::Loader::runInitializersBottomUpPlusUpwardLinks(dyld4::RuntimeState&) const + 108
5 dyld 0x1148dee00 dyld4::APIs::dlopen_from(char const*, int, void*) + 592
6 CoreFoundation 0x7ff815cd6994 _CFBundleDlfcnLoadBundle + 149
7 CoreFoundation 0x7ff815d5094f _CFBundleLoadExecutableAndReturnError + 484
8 AudioToolboxCore 0x7ff81712efa5 APComponent_FromBundle_Loadable::ResolveFactoryFunction() + 67
9 AudioToolboxCore 0x7ff81712ded2 APComponent::newInstance(unsigned int, bool, void (OpaqueAudioComponentInstance*, int) block_pointer) + 126
10 AudioToolboxCore 0x7ff817223c90 instantiate(OpaqueAudioComponent*, unsigned int, bool, void (OpaqueAudioComponentInstance*, int) block_pointer) + 311
11 AudioToolboxCore 0x7ff81722402c __AudioComponentInstanceNew_block_invoke + 88
12 AudioToolboxCore 0x7ff8170b5479 Synchronously + 87
13 AudioToolboxCore 0x7ff817223ee2 AudioComponentInstanceNew + 183
14 <AppName> 0x10f9274e3 mx::EditableDevice::instanciate(AudioComponentDescription*, unsigned short, unsigned char) + 77
15 <AppName> 0x10f9273cf mx::EditableDevice::EditableDevice(mx::MixerBase*, AudioComponentDescription*, unsigned short, bool) + 101
16 <AppName> 0x10f9087ab mx::Insert::Insert(mx::MixerBase*, AudioComponentDescription*, unsigned char, unsigned char, unsigned char) + 41
17 <AppName> 0x10f90e957 mx::Track::insertEffectAtIndex(unsigned long long, unsigned char, unsigned char, unsigned char, unsigned char) + 559