How to Successfully Boot macOS with Your Audio Interface Connected Without Crashes Hello everyone! A huge thank you to matt9 and all of you. Thanks to your help, I was able to install my Prism Sound Orpheus on Sequoia successfully! YES It works on Sequoia I have found a way to restart the computer or boot without having to disconnect the interface. Prevent IOFireWireAVC.kext from Loading Steps to Block the Kext: Open Terminal and create a configuration file to block the kext: sudo nano /Library/Extensions/BlockFireWireAVC.conf Paste the following line into the file: Restrict com.apple.iokit.IOFireWireAVC Save the file by pressing CTRL + X, then Y, then ENTER. Block the kext from loading at boot using nvram: sudo nvram boot-args="kext-dev-mode=1 kextblock=com.apple.iokit.IOFireWireAVC" Restart your Mac normally with the FireWire audio interface connected. Your FireWire device should now work without needing to be unplugged when rebooting, while also avoiding Wi-Fi issues and system crashes. If you encounter any issues, you can reset the changes using: sudo nvram -d boot-args The only remaining issue is that when the computer goes into sleep or standby mode, it crashes after about one minute upon waking up. Therefore, it is recommended to disconnect the interface before waking the computer. For those who have experienced issues installing the matt9 pkg and its kext AppleFWAudio.kext, very important: The operating system must be installed on an internal disk, not on an external SSD. If you want to keep your current system running, you can create a new volume using Disk Utility and install macOS Sequoia there, keeping both systems separate.