I too received a similar error after trying to install Monterey Beta - which yields the softwareupdate service losing its brain 2021-08-13 20:16:54-04 ittybitty osinstallersetupd[25675]: Failed to start brain: Error Domain=SUMacControllerError Code=7721 "[SUMacControllerErrorPreflightWakeupFailed=7721] Failed to perform PreflightWakeup operation: [MobileSoftwareUpdateErrorDomain(MSU):MSU_ERR_INTERNAL_ERROR(7)]" UserInfo={NSLocalizedDescription=Failed to launch the software update installer. Please try again., SUMacControllerErrorIndicationsMask=0, NSDebugDescription=[SUMacControllerErrorPreflightWakeupFailed=7721] Failed to perform PreflightWakeup operation: [MobileSoftwareUpdateErrorDomain(MSU):MSU_ERR_INTERNAL_ERROR(7)], NSUnderlyingError=0x6000015ac6f0 {Error Domain=MobileSoftwareUpdateErrorDomain Code=7 "No service connection" UserInfo={NSLocalizedDescription=No service connection}}}