I experienced the same issue in my environment (XCode 16.2, Intel MBP, iOS Simulator).
However after getting "Couldn't find the Objective-C runtime library in loaded images" at the first breakpoint, manually attaching the debugger allowed subsequent breakpoints to function properly.
Therefore, I'm using the following workaround by running without a debugger and attaching manually:
Product > Scheme > Edit Scheme...
Choose "Run" from left pane.
In the "Info" tab of right pane, uncheck "Debug executable"
Run Application
Debug > Attach to Process > (Choose Your Simulator from the top of the list)
Since I've just started using this method, I can't guarantee it will always work, but it might be helpful for debugging except for the very initial startup phase.
Topic:
Developer Tools & Services
SubTopic:
Xcode
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