Started having this issue with Sonoma and upgraded to Sequoia hoping that it would fix it. Now I'm running macOS Sequoia 15.2, XCode 16.2 and I can confirm the problem still happens. AlexBlack's workaround of launching the application manually works for me. I am building a native macOS application, though, not an iOS one as the OP. Sometimes (not always) the debugger pauses and shows machine code, and it looks like it's related to my breapoint because if I disable it, the debugger no longer pauses. At some point, though, it just stops responding even if I re-enable the brekpoint. "Always show disassembly" is unchecked.