Same, Monterey, External SSD (thunderbolt connected, but also tested USB connected with same issue). RME Drivers not loading, trying to launch the kext manually: sudo kextutil /Library/Extensions/FirefaceAudioDriver.kext Results in: Executing: /usr/bin/kmutil load --bundle-path /Library/Extensions/FirefaceAudioDriver.kext Error Domain=KMErrorDomain Code=71 "Could not find: Unable to get contents of boot kernel collection collection at /System/Volumes/Preboot/45F3B5D9-3EE1-4237-8AE0-10214A7CAF9A/boot/4E3C25B8EDD6ABA7DAA7645086088087F6DDF6E795D635E64369912FF476CB289E6197136983317DBD7E04C161F4B7EC/System/Library/Caches/com.apple.kernelcaches/kernelcache" UserInfo={NSLocalizedDescription=Could not find: Unable to get contents of boot kernel collection collection at /System/Volumes/Preboot/45F3B5D9-3EE1-4237-8AE0-10214A7CAF9A/boot/4E3C25B8EDD6ABA7DAA7645086088087F6DDF6E795D635E64369912FF476CB289E6197136983317DBD7E04C161F4B7EC/System/Library/Caches/com.apple.kernelcaches/kernelcache}