In case it helps anyone who faces this issue but their app is actually using Game Center: My app's main target (the only one using Game Center functionality) had everything set up fine (App ID/entitlements file/capabilities). I took a look at my WatchKit app and WatchKit app extension targets and that turned out to be the issue - even though my app does not use Game Center on the watch. In developer portal, I turned Game Center on for both WatchKit app and WatchKit extension IDs (under Certificates, Identifiers & Profiles -> Identifiers) In Xcode, I turned on the Game Center capability in the WatchKit extension target (which in turn created an .entitlements file for that target) I forced a re-creation of the automatically managed provision profiles (deleted everything under ~/Library/MobileDevice/Provisioning\ Profiles) Uploading a new build had no issue anymore and I could successfully submit the app.

Issue is still happening for me. Trying to add the build for review returns App Store Connect error (Network inspector) "status" : "409", "code" : "STATE_ERROR.BUILD_INDICATES_GAME_CENTER_DISABLED", "title" : "Your build indicates game center is disabled.", "detail" : "Your appStoreVersion has gameCenterConfigurations relationship but build is missing com.apple.developer.game-center key." The game center entitlement though does exist in the build - going to the selected build details in App Store Connect shows it's there and set to true. Re-enabling capability does not work, re-enabling automatic signing does not work, Xcode is setup properly.