@phirk i have the same issue with cisco anyconnect. I actually had a 1 on 1 lab session with the xcode team during WWDC regarding this. They changed the stack from previous xcodes to a new stack called CoreDevice i belive. its mosty a network connection, so when cisco connects it 'kills' those devices and immediatly on cicsco disconnect it sees them again. Its a pain to have to disconnect to be able to debug on a device. i also submitted a feedback with as many details as possible about our cisco setup. They are looking into it, but it might not be a Apple thing. It could be Cisco Anyconnect and it also could be how its setup at your workplace. So as of right now its kinda an outstanding issue with no solution atm.
Topic:
Developer Tools & Services
SubTopic:
Xcode
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